Endocrine Abstracts

Women with positive thyroid autoimmunity are considered at risk of developing hypothyroidism in pregnancy, so monitoring thyroid function is recommended.Objective: To assess the risk of gestational hypothyroidism in pregnant women with autoimmune thyroid disease and normal thyrotropin (TSH) at the beginning of pregnancy.Methods: Retrospective review of data from pregnant women attended between April 2016 and October 2019. Women wit...

ContextThe incidence of Type 2 diabetes mellitus (T2DM) is increasing and muscle strength and function are reported to be decreased in patients with T2DM compared to healthy controls.However, the relation between bone and muscle remain unclear.ObjectiveOur aims was to examine bone health parameters [by Dual energy X-ray absorptiometry (DXA) and trabecular bone score (TBS)] and muscle strength (by hand grip) i...

Introduction and objectivesThyroid cancer treatment tends to be individualized based on risk stratification and increasingly less aggressive for low-risk tumors, as recent studies have shown that low doses of I-131 are just as effective than higher doses with excellent remission rates. The objective of our study was to evaluate the response after 1 year of treatment with 30 mCi of I-131 in patients with differentiated thyroid cancer.<p class="abstext...

Introduction: Inferior petrosal sinus sampling (IPSS) is considered to be the gold standard for confirming the source of ACTH secretion in patients with Cushing’s syndrome (CS). Prolactin measurement during IPSS can improve diagnostic accuracy and reduces false negative responses.Patients and methods: 56 patients with ACTH-dependent CS were included (45 F/11 M, mean age 43.6±10.8 years and 90.1% Cushing’s disease) diagnosed since 2000. IPS...

Alterations in (small) intestinal microbiota are associated with obesity and insulin resistance, with the latter usually characterized by low grade endotoxemia. We recently showed that fecal transplantation (infusing intestinal microbiota from lean donors) in male recipients with metabolic syndrome has beneficial effects on the recipients’ microbiota composition and glucose metabolism via lowering plasma endotoxin levels (Vrieze, Gastroenterology 2012). Moreover, prelimin...

Ronald M Evans, The Salk Institute for Biological Studies, LaJolla, California, USA Abstracthttp://www.endocrine-abstracts.org/ea/0031/ea0031pl1biog.htm...

M Kawata, Kyoto Prefectural University of Medicine, Kyoto, Japan AbstractMitsuhiro Kawata is Professor of Anatomy and Neurobiology at Kyoto Prefectural University of Medicine. He received both an MD and a PhD from Kyoto Prefectural University of Medicine and has spent his scientific career at the Rockefeller University and University of Edinburgh. His research interests over time lie in the search for the mechanism of ...

Background: RACE is an open-label study that assessed the long-term safety and efficacy of recombinant human parathyroid hormone 1–84 (rhPTH[1–84]) for the treatment of hypoparathyroidism in adults (ClinicalTrials.gov identifier NCT01297309). Here, we present 6-year safety and efficacy data.Methods: Patients initially received 25 or 50 μg of rhPTH(1–84) subcutaneously, once daily, with stepwise dose adjustments of 25 μg (up or do...

Hypoparathyroidism (HPT) is characterised by hypocalcaemia and impaired renal phosphate excretion and calcium conservation. Oral calcium supplements and calcitriol can improve serum calcium levels but lack the physiologic effects of PTH on renal reabsorption of calcium. RACE is an ongoing open-label study evaluating the long-term safety of recombinant human parathyroid hormone 1-84 (rhPTH[1-84], parathyroid hormone rDNA) in adults with HPT (NCT01297309). In this interim analys...

PARADIGHM™, a global, prospective, observational registry of patients with chronic hypoparathyroidism (HPT), began enrolment in 2013 to collect data on the natural history of chronic HPT (ClinicalTrials.gov NCT01922440). Since initiation, recombinant human PTH, rhPTH(1-84), has been approved in the United States and Europe as an adjunctive treatment for adult patients with HPT. The protocol for the registry (now a European Medicines Agency–designated postm...